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Ouabain increases neuronal branching in hippocampus and improves spatial memory

Ouabain increases neuronal branching in hippocampus and improves spatial memory

Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory regulation. This study investigated the effects of OUA (10nM) […]

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PREMIO JOVEM TALENTO – Paula Fernanda Kinoshita

PREMIO JOVEM TALENTO – Paula Fernanda Kinoshita

PREMIO JOVEM TALENTO A Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq) e a GE Healthcare Life Sciences anuncia o resultado premiliminar do 22 Prêmio Jovem Talento em Ciências da Vida, edição 2018 A Comissão encarregada de selecionar os candidatos foi constituída pelos seguintes membros: Prof. Dr. Richard C. Garratt – IFSC-USP e Vice-Presidente da […]

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Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis

Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis

Estudos comprovam benefícios da “proteína da longevidade” no cérebro. A Proteína Klotho é antioxidante, anti-inflamatória e vital para a produção de lactato, um dos alimentos dos neurônios. Na mitologia grega, as moiras eram três mulheres que fabricavam, teciam e cortavam o fio da vida de homens e deuses. Uma delas, de nome Klotho, era responsável […]

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(English) Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

(English) Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. Kinoshita PF, Yshii LM, Orellana AMM, Paixão AG, Vasconcelos AR, Lima LS, Kawamoto EM, Scavone C. – Ouabain (OUA) is a cardiac glycoside that binds to Na+,K+-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires […]

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(English) Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders

(English) Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders

Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders Jacqueline A. Leite*, Ana Maria M. Orellana*, Paula F. Kinoshita*, Natália P. de Mello*, Cristoforo Scavone, Elisa M. Kawamotoδ Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, Brazil Abstract: Some classical psychiatric disorders such as schizophrenia, autism, major depression, bipolar and obsessive-compulsive disorders have been […]

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(English) The relevance of α-KLOTHO to the Central Nervous System: some key questions

(English) The relevance of α-KLOTHO to the Central Nervous System: some key questions

α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α-Klotho is also expressed in the choroid plexus, where it is released into the cerebrospinal fluid. Nonetheless, α-Klotho is also expressed in the brain parenchyma. Accumulating evidence indicates […]

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The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence

The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence

Decreased Na(+), K(+)-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β, and γ, with four distinct isoforms of the catalytic α subunit (α1-4). Genetic mutations in the ATP1A2 gene and ATP1A3 gene, encoding the α2 and α3 subunit isoforms, respectively can cause […]

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The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions

The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions

Steroid hormones, such as sex hormones and glucocorticoids, have been demonstrated to play a role in different cellular processes in the central nervous system, ranging from neurodevelopment to neurodegeneration. Environmental factors, such as calorie intake or fasting frequency, may also impact on such processes, indicating the importance of external factors in the development and preservation […]

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Cardiotonic Steroids as Modulators of Neuroinflammation.

Cardiotonic Steroids as Modulators of Neuroinflammation.

Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. […]

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Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Aging is a multifactorial process associated with an increased susceptibility to neurodegenerative disorders which can be related to chronic inflammation. Chronic inflammation, however, can be characterized by the persistent elevated glucocorticoid (GCs) levels, activation of the proinflammatory transcription factor NF-кB, as well as an increase in cytokines. Interestingly, both NF-кB and cytokines can be even […]