Effects of Intermittent Fasting on Age-Related Changes on Na,K-ATPase Activity and Oxidative Status Induced by LPS In Rat Hippocampus.


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Chronic neuroinflammation is a common characteristic of neurodegenerative diseases, and lipopolysaccharide(LPS) signalling is linked to glutamate-nitric oxide (NO)-Na,K-ATPase isoforms pathway in central nervous system(CNS) and also causes neuroinflammation.. Intermitent fasting(IF) induces adaptive responses in the brain that can suppress inflammation but the age-related effect of IF on LPS modulatory influence on NO-Na,K-ATPase isoforms is unknown. This work compared the effects of LPS on the activity of α12,3 Na,K-ATPase, NOS gene expression and/or activity, cyclic GMP, and TBARS levels in CNS of young and aged rats submitted to the protocol of IF for 30 days. LPS induced an age-related effect in neuronal NOS activity, cyclic GMP and TBARs levels in rat hippocampus which was linked to changes in α2,3-Na,K-ATPase activity and iNOS gene expression. IF induced adaptative cellular stress-response signalling pathways reverting LPS effects in rat hippocampus of young and aged rats. The results suggest that IF in both ages would reduce the risk for deficits on brain function and neurodegenerative disorders linked to inflammatory response in CNS.