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Welcome to a new site Laboratório de Neurofarmacologia Molecular da USP !

FotoCNPqResearch Laboratory employs a multifaceted array of experimental models of aging and age-related neurodegenerative disorders in order to establish the molecular and biochemical changes that occur during aging and in disorders such as Alzheimer’s and Parkinson’s diseases. An area of focus is aimed at understanding adaptive cellular stress responses in neurons, and how they can be activated by behavioral and pharmacological interventions so as to protect the brain against injury and disease.

Data obtained in these experimental models are integrated with data obtained in studies of both normal elderly humans and patients with neurodegenerative disorders to arrive at conclusions as to why neuronal dysfunction and degeneration occur in the disorders.  Discoveries made in animal models in the laboratory are being translated into preclinical studies and clinical trials in human subjects.

Segundo Elisa Kawamoto, um dos desafios da ciência é descobrir o que há de diferente no cérebro de quem envelhece sadiamente e daquele que desenvolve uma doença degenerativa. Foto: Francisco Emolo

Cristoforo Scavone, PhD & Elisa Kawamoto, PhD Pharmacology Department – Institute of Biomedical Sciences – University of São Paulo

Molecular and Functional Neurobiology Laboratory – Changes in cognitive abilities are a typical feature of the normal aging process, as well as of many chronic neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and Huntington’s diseases. Although the etiology is different, a common hallmark amongst all these disorders is neuroinflammation. In the last decade clinical trials held to determine the efficacy of anti-inflammatory drugs in preventing cognitive decline have given contradictory results. Thus, it is necessary to further our knowledge on the complex, and still elusive role of the inflammatory process in cognitive dysfunction. It also emphasizes the requirement to identify therapeutic agents with pleiotropic rather than mere anti-inflammatory properties.

Cristoforo Scavone, professor do ICB e Marina Cararo , mestranda no laboratório de Neurofarmacologia Molecular.Foto: Cecilia Bastos/USP Imagem

Cristoforo Scavone, professor do ICB e Marina Cararo , mestranda no laboratório de Neurofarmacologia Molecular.Foto: Cecilia Bastos/USP Imagem