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Ouabain increases neuronal branching in hippocampus and improves spatial memory

Ouabain increases neuronal branching in hippocampus and improves spatial memory

Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory regulation. This study investigated the effects of OUA (10nM) […]

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Young Talent Award

Young Talent Award

The importance of alpha 2 Na+, K+- ATPase in neuroinflammation P.F.Kinoshita, A.M.M. Orellana,J.A. Leite, D.Z. Andreotti, L. de Sá Lima, E.M.Kawamoto & C. Scavone Molecular Neuropharmacology Laboratory, Department of Pharmacology,ICB-USP. Na,K-ATPase (NKA) is a membrane protein essential for life because NKA plays a role in membrane gradient maintenance. So far, 4 isoforms of alpha subunit […]

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(Português) Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis

(Português) Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18762700. doi: 10.1177/0271678X18762700. Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function. Although highly expressed in specific areas of the brain, Klotho functions in the central nervous system remain unknown. Here, we show that cultured […]

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Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. Kinoshita PF, Yshii LM, Orellana AMM, Paixão AG, Vasconcelos AR, Lima LS, Kawamoto EM, Scavone C. – Ouabain (OUA) is a cardiac glycoside that binds to Na+,K+-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires […]

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Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders

Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders

Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders Jacqueline A. Leite*, Ana Maria M. Orellana*, Paula F. Kinoshita*, Natália P. de Mello*, Cristoforo Scavone, Elisa M. Kawamotoδ Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, Brazil Abstract: Some classical psychiatric disorders such as schizophrenia, autism, major depression, bipolar and obsessive-compulsive disorders have been […]

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The relevance of α-KLOTHO to the Central Nervous System: some key questions

The relevance of α-KLOTHO to the Central Nervous System: some key questions

α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α-Klotho is also expressed in the choroid plexus, where it is released into the cerebrospinal fluid. Nonetheless, α-Klotho is also expressed in the brain parenchyma. Accumulating evidence indicates […]

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(Português) The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence

(Português) The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence

Sorry, this entry is only available in Brazilian Portuguese.

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(Português) The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions

(Português) The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions

Sorry, this entry is only available in Brazilian Portuguese.

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(Português) Cardiotonic Steroids as Modulators of Neuroinflammation.

(Português) Cardiotonic Steroids as Modulators of Neuroinflammation.

Sorry, this entry is only available in Brazilian Portuguese.

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(Português) Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

(Português) Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Aging is a multifactorial process associated with an increased susceptibility to neurodegenerative disorders which can be related to chronic inflammation. Chronic inflammation, however, can be characterized by the persistent elevated glucocorticoid (GCs) levels, activation of the proinflammatory transcription factor NF-кB, as well as an increase in cytokines. Interestingly, both NF-кB and cytokines can be even […]